There’s a project which is currently being completed for that scenario, the Mose: https://en.wikipedia.org/wiki/MOSE

It is directly supported and maintained from Google, which then bases Chrome on that project adding some proprietary code. So I think yes, it is doomed

NewPipe with SponsorBlock https://github.com/polymorphicshade/NewPipe

Not really, but they are alternatives to each other. Bottles can also be configured to run “normal” applications alongside possible games and stuff, while Lutris has more a “gaming” UI vibes (but you can run everything you want on both of them really) and additionally provides some integrations for other emulators. I think it comes down to personal tastes at the end of the day, both of them under the hood use wine/proton and apply settings to it before running the application