This is not true. The extra methyl group makes it cross the blood brain barrier faster. The extra potency is from the drug itself being different from dexampphetamine, the active ingredient in adderall, however it is important to note that at doses below 50 mg methamphetamine and 100mg adderall, effects are almost entirely the same, with the serotoninergic (is this a word ?) aspects of meth only coming from high doses.
If something hits harder and faster, I’m pretty sure definitionally its more potent.
Potency is a function of its effect relative to the amount used. Like this is more of “yes, AND” type deal, I’m not wrong and you’re right to elaborate that this is due to its increased abillity to permeate BBB
different from dextroamphetamine
Unless we’re getting into racemics , I’m saying its basically amphetamine + methyl group, lets not get so granular here
Also, meth and amphetamine can be taken such that the doses are equipotent, it would just be less meth and more amphetamine by weight/dosage (all other things like ROA and context being equal)
Re:Serotonin: I believe amphet and meth both affect serotonin dose dependant but I dont think there’s any way to say only meth also implicates serotonergic release or transmission
Thank you! I’m normally the crank making this comment. Also don’t forget for the heroin example that the acetyl groups get cleaved after crossing the BBB so it goes back to being regular ol’ morphine before it can bind to a receptor.
This is not true. The extra methyl group makes it cross the blood brain barrier faster. The extra potency is from the drug itself being different from dexampphetamine, the active ingredient in adderall, however it is important to note that at doses below 50 mg methamphetamine and 100mg adderall, effects are almost entirely the same, with the serotoninergic (is this a word ?) aspects of meth only coming from high doses.
Do not recommend either.
If something hits harder and faster, I’m pretty sure definitionally its more potent.
Potency is a function of its effect relative to the amount used. Like this is more of “yes, AND” type deal, I’m not wrong and you’re right to elaborate that this is due to its increased abillity to permeate BBB
Unless we’re getting into racemics , I’m saying its basically amphetamine + methyl group, lets not get so granular here
Also, meth and amphetamine can be taken such that the doses are equipotent, it would just be less meth and more amphetamine by weight/dosage (all other things like ROA and context being equal)
Re:Serotonin: I believe amphet and meth both affect serotonin dose dependant but I dont think there’s any way to say only meth also implicates serotonergic release or transmission
Thank you! I’m normally the crank making this comment. Also don’t forget for the heroin example that the acetyl groups get cleaved after crossing the BBB so it goes back to being regular ol’ morphine before it can bind to a receptor.
Serotonergic which is minor in high amphetamine doses, they’re more dopaminergic. Serotonin is more SSRIs and psychedelics.