Talarico was an outspoken critic of legislation that would have required the display of the Ten Commandmentsin all elementary and secondary classrooms, on the constitutional grounds of separation of church and state. He called the measure “un-American” and “un-Christian”.[43]

In 2025, he continued to be a major voice in opposition to placing the Ten Commandments in Texas public schools. The specific legislation, SB 10, required every classroom to visibly display a poster containing the Ten Commandments, sized at least 16 by 20 inches. When the bill was first brought to the floor of the Texas House, Talarico called a point of order that delayed its passage.[47]

In a 2023 guest sermon, Talarico called Christian nationalism “the worship of power—social power, economic power, political power, in the name of Christ”. He has said Christian nationalists have turned Jesus “into a gun-toting, gay-bashing, science-denying, money-loving, fear-mongering fascist”, arguing that it is “incumbent on all Christians to confront it and denounce it”.[83]