During a recent panel aboard the Star Trek Cruise ship (via Screen Rant), Marina Sirtis stated Star Trek: Legacy is “never going to happen.”
Marina Sirtis: First of all, Legacy is never gonna happen.
Jonathan Frakes: Come on, Marina!
Marina Sirtis: You know, you hate hearing the truth. There is not a single studio in America that is gonna make a series where most of the leading actors are over 70 years old. I’m sorry, but that’s just the truth. It’s just Hollywood.



It’s at about 43:00 in the embedded video, and yeah, that’s probable, but the question was posed to the panel about what their characters would explore in a hypothetical Legacy show, so unless she’s been right on top of it, it feels like a fair assumption for her to have made that they’d be among the leads.
As an aside, I think I would absolutely love hanging out with Marina Sirtis for exactly one day, and I would be utterly exhausted at the idea of spending any longer than that. In her interviews, she is always a delight, but also a lot.
Sirtis is a lot more like Lwaxana than Troi ever was. Also, @29:48 in the same video: